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THTRI is expressed widely in human tisseues with particular high expression in skeletal muscles, placenta, heart liver and kidney [168, 170].Mutations in the SLC19A2 (D93H, S143F and G172D) cause malfunctioning of the thiamine transporter THTR1, thiamine deficiency and thiamine responsive megaloblastic anaemia (TRMA) [171, 172]

they were mainly concerned about overprescribing, clinically ijnappropriate prescribing (cited by 56% of doctors), continuity of care such as follow-up visits, lack of holistic care, medication interactions, side effect management, titration, and/or tapering off the medication

doi: 10.5624/isd.2014.44.4.325 58 OuY.-N.XuW.LiJ.-Q.GuoY.CuiM.ChenK.-L.et al

Moreover, defects in glucose and fatty acid metabolism result in intracellular accumulation of fatty acids and glycolytic intermediates